Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions. / Specht, Ina Olmer; Hougaard, Karin S; Spanò, Marcello; Bizzaro, Davide; Manicardi, Gian Carlo; Lindh, Christian H; Toft, Gunnar; Jönsson, Bo A G; Giwercman, Aleksander; Bonde, Jens Peter E.

In: Reproductive Toxicology, Vol. 33, No. 4, 2012, p. 577-83.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Specht, IO, Hougaard, KS, Spanò, M, Bizzaro, D, Manicardi, GC, Lindh, CH, Toft, G, Jönsson, BAG, Giwercman, A & Bonde, JPE 2012, 'Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions', Reproductive Toxicology, vol. 33, no. 4, pp. 577-83. https://doi.org/10.1016/j.reprotox.2012.02.008

APA

Specht, I. O., Hougaard, K. S., Spanò, M., Bizzaro, D., Manicardi, G. C., Lindh, C. H., Toft, G., Jönsson, B. A. G., Giwercman, A., & Bonde, J. P. E. (2012). Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions. Reproductive Toxicology, 33(4), 577-83. https://doi.org/10.1016/j.reprotox.2012.02.008

Vancouver

Specht IO, Hougaard KS, Spanò M, Bizzaro D, Manicardi GC, Lindh CH et al. Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions. Reproductive Toxicology. 2012;33(4):577-83. https://doi.org/10.1016/j.reprotox.2012.02.008

Author

Specht, Ina Olmer ; Hougaard, Karin S ; Spanò, Marcello ; Bizzaro, Davide ; Manicardi, Gian Carlo ; Lindh, Christian H ; Toft, Gunnar ; Jönsson, Bo A G ; Giwercman, Aleksander ; Bonde, Jens Peter E. / Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions. In: Reproductive Toxicology. 2012 ; Vol. 33, No. 4. pp. 577-83.

Bibtex

@article{116c978c729b416baade3815b13828c6,
title = "Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions",
abstract = "Perfluoroalkyl substances (PFASs) can interfere with male reproductive function, but evidence in humans is limited. Six hundred four fertile men (199 from Greenland, 197 from Poland and 208 from Ukraine) were enrolled in the study. We measured four PFASs in serum (PFOS, PFOA, PFNA and PFHxS) and concurrent DNA damage in spermatozoa by sperm chromatin structure assay (SCSA) and in situ terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay, apoptotic markers in semen (Fas-receptor and Bcl-xL), and reproductive hormones in serum. No association between PFASs and SCSA, apoptotic markers or reproductive hormones emerged. We observed a slight increase in SHBG and TUNEL-positivity with increased PFOA exposure in men from Greenland. Thus, consistent evidence that PFAS exposure interferes with sperm DNA fragmentation, apoptosis or reproductive hormones was not found.",
author = "Specht, {Ina Olmer} and Hougaard, {Karin S} and Marcello Span{\`o} and Davide Bizzaro and Manicardi, {Gian Carlo} and Lindh, {Christian H} and Gunnar Toft and J{\"o}nsson, {Bo A G} and Aleksander Giwercman and Bonde, {Jens Peter E}",
note = "Copyright {\textcopyright} 2012 Elsevier Inc. All rights reserved.",
year = "2012",
doi = "10.1016/j.reprotox.2012.02.008",
language = "English",
volume = "33",
pages = "577--83",
journal = "Reproductive Toxicology",
issn = "0890-6238",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances - a study of spouses of pregnant women in three geographical regions

AU - Specht, Ina Olmer

AU - Hougaard, Karin S

AU - Spanò, Marcello

AU - Bizzaro, Davide

AU - Manicardi, Gian Carlo

AU - Lindh, Christian H

AU - Toft, Gunnar

AU - Jönsson, Bo A G

AU - Giwercman, Aleksander

AU - Bonde, Jens Peter E

N1 - Copyright © 2012 Elsevier Inc. All rights reserved.

PY - 2012

Y1 - 2012

N2 - Perfluoroalkyl substances (PFASs) can interfere with male reproductive function, but evidence in humans is limited. Six hundred four fertile men (199 from Greenland, 197 from Poland and 208 from Ukraine) were enrolled in the study. We measured four PFASs in serum (PFOS, PFOA, PFNA and PFHxS) and concurrent DNA damage in spermatozoa by sperm chromatin structure assay (SCSA) and in situ terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay, apoptotic markers in semen (Fas-receptor and Bcl-xL), and reproductive hormones in serum. No association between PFASs and SCSA, apoptotic markers or reproductive hormones emerged. We observed a slight increase in SHBG and TUNEL-positivity with increased PFOA exposure in men from Greenland. Thus, consistent evidence that PFAS exposure interferes with sperm DNA fragmentation, apoptosis or reproductive hormones was not found.

AB - Perfluoroalkyl substances (PFASs) can interfere with male reproductive function, but evidence in humans is limited. Six hundred four fertile men (199 from Greenland, 197 from Poland and 208 from Ukraine) were enrolled in the study. We measured four PFASs in serum (PFOS, PFOA, PFNA and PFHxS) and concurrent DNA damage in spermatozoa by sperm chromatin structure assay (SCSA) and in situ terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay, apoptotic markers in semen (Fas-receptor and Bcl-xL), and reproductive hormones in serum. No association between PFASs and SCSA, apoptotic markers or reproductive hormones emerged. We observed a slight increase in SHBG and TUNEL-positivity with increased PFOA exposure in men from Greenland. Thus, consistent evidence that PFAS exposure interferes with sperm DNA fragmentation, apoptosis or reproductive hormones was not found.

U2 - 10.1016/j.reprotox.2012.02.008

DO - 10.1016/j.reprotox.2012.02.008

M3 - Journal article

C2 - 22449571

VL - 33

SP - 577

EP - 583

JO - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

IS - 4

ER -

ID: 48432016