The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample
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The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample. / Esserlind, Ann-Louise; Christensen, Anne Francke; Steinberg, Stacy; Grarup, Niels; Pedersen, Oluf; Hansen, Torben; Werge, Thomas; Hansen, Thomas Folkmann; Husemoen, Lise Lotte N; Linneberg, Allan René; Budtz-Jørgensen, Esben; Westergaard, Maria Lurenda; Stefansson, Hreinn; Olesen, Jes.
In: Cephalalgia : an international journal of headache, Vol. 36, No. 7, 2016, p. 1-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample
AU - Esserlind, Ann-Louise
AU - Christensen, Anne Francke
AU - Steinberg, Stacy
AU - Grarup, Niels
AU - Pedersen, Oluf
AU - Hansen, Torben
AU - Werge, Thomas
AU - Hansen, Thomas Folkmann
AU - Husemoen, Lise Lotte N
AU - Linneberg, Allan René
AU - Budtz-Jørgensen, Esben
AU - Westergaard, Maria Lurenda
AU - Stefansson, Hreinn
AU - Olesen, Jes
N1 - © International Headache Society 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
PY - 2016
Y1 - 2016
N2 - INTRODUCTION: The objective of the study was to follow up and to test whether 12 previously identified migraine-associated single nucleotide polymorphisms were associated as risk factors and/or modifying factors for severe migraine traits in a Danish clinic-based population.METHODS: Semi-structured migraine interviews, blood sampling and genotyping were performed on 1806 unrelated migraineurs recruited from the Danish Headache Center. Genotyping was also performed on a control group of 6415 people with no history of migraine. Association analyses were carried out using logistic regression and odds ratios were calculated assuming an additive model for risk. The proxies for severe migraine traits (early onset of migraine; many lifetime attacks, prolonged migraine and tendency to chronification of migraine) were tested against the 12 single nucleotide polymorphisms and a combined genetic score in both a case-control and case-only logistic regression model.RESULTS: We successfully replicated five out of the 12 previously reported loci and confirmed the same direction of effects for all the 12 single nucleotide polymorphisms. In line with the recently published genome-wide association meta-analysis, the associations were significant for all migraine and migraine without aura but not for migraine with typical aura. Two single nucleotide polymorphisms (rs2274316 and rs11172113) conferred risk of many lifetime attacks inthe case-control analysis. In the case-only analysis, only three single nucleotide polymorphisms showed nominal association with many lifetime attacks and prolonged migraine attacks.CONCLUSION: Our study supports previously reported findings on the association of several single nucleotide polymorphisms with migraine. It also suggests that the migraine susceptibility loci may be risk factors for severe migraine traits.
AB - INTRODUCTION: The objective of the study was to follow up and to test whether 12 previously identified migraine-associated single nucleotide polymorphisms were associated as risk factors and/or modifying factors for severe migraine traits in a Danish clinic-based population.METHODS: Semi-structured migraine interviews, blood sampling and genotyping were performed on 1806 unrelated migraineurs recruited from the Danish Headache Center. Genotyping was also performed on a control group of 6415 people with no history of migraine. Association analyses were carried out using logistic regression and odds ratios were calculated assuming an additive model for risk. The proxies for severe migraine traits (early onset of migraine; many lifetime attacks, prolonged migraine and tendency to chronification of migraine) were tested against the 12 single nucleotide polymorphisms and a combined genetic score in both a case-control and case-only logistic regression model.RESULTS: We successfully replicated five out of the 12 previously reported loci and confirmed the same direction of effects for all the 12 single nucleotide polymorphisms. In line with the recently published genome-wide association meta-analysis, the associations were significant for all migraine and migraine without aura but not for migraine with typical aura. Two single nucleotide polymorphisms (rs2274316 and rs11172113) conferred risk of many lifetime attacks inthe case-control analysis. In the case-only analysis, only three single nucleotide polymorphisms showed nominal association with many lifetime attacks and prolonged migraine attacks.CONCLUSION: Our study supports previously reported findings on the association of several single nucleotide polymorphisms with migraine. It also suggests that the migraine susceptibility loci may be risk factors for severe migraine traits.
U2 - 10.1177/0333102415570492
DO - 10.1177/0333102415570492
M3 - Journal article
C2 - 25667298
VL - 36
SP - 1
EP - 9
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 7
ER -
ID: 135493341