TY - JOUR

T1 - The association between meat and fish consumption and bladder cancer risk

T2 - a pooled analysis of 11 cohort studies

AU - Dianatinasab, Mostafa

AU - Wesselius, Anke

AU - de Loeij, Tessa

AU - Salehi-Abargouei, Amin

AU - Yu, Evan Y. W.

AU - Fararouei, Mohammad

AU - Brinkman, Maree

AU - van den Brandt, Piet

AU - White, Emily

AU - Weiderpass, Elisabete

AU - Le Calvez-Kelm, Florence

AU - Gunter, Marc J.

AU - Huybrechts, Inge

AU - Liedberg, Fredrik

AU - Skeie, Guri

AU - Tjonneland, Anne

AU - Riboli, Elio

AU - Zeegers, Maurice P.

PY - 2021

Y1 - 2021

N2 - Evidence on the effects of meat consumption from different sources on the risk of bladder cancer (BC) is limited and controversial. Therefore, this study aimed to evaluate the associations between meat consumption and BC risk using a pooled data approach. Individual data from 11 prospective cohorts comprising 2848 BC cases and 515,697 non-cases with a total of 5,498,025 person-years of follow-up was pooled and analysed to investigate the potential associations between total red meat and products, red meat, processed meat, poultry and total fish and BC risk. Hazard ratios (HRs), with corresponding 95% confidence intervals (CIs), were estimated using Cox regression models stratified on cohort. Overall, an increased BC risk was found for high intake of organ meat (HR comparing highest with lowest tertile: 1.18, 95% CI: 1.03, 1.36, p-trend = 0.03). On the contrary, a marginally inverse association was observed for total fish intake and BC risk among men (HR comparing highest with lowest tertile: 0.79, 95% CI 0.65, 0.97, p-trend = 0.04). No associations were observed for other meat sources. Results of this prospective study suggest that organ meat consumption may be associated with BC development. Replication in large-scale prospective studies and investigation of possible causal mechanisms is needed.

AB - Evidence on the effects of meat consumption from different sources on the risk of bladder cancer (BC) is limited and controversial. Therefore, this study aimed to evaluate the associations between meat consumption and BC risk using a pooled data approach. Individual data from 11 prospective cohorts comprising 2848 BC cases and 515,697 non-cases with a total of 5,498,025 person-years of follow-up was pooled and analysed to investigate the potential associations between total red meat and products, red meat, processed meat, poultry and total fish and BC risk. Hazard ratios (HRs), with corresponding 95% confidence intervals (CIs), were estimated using Cox regression models stratified on cohort. Overall, an increased BC risk was found for high intake of organ meat (HR comparing highest with lowest tertile: 1.18, 95% CI: 1.03, 1.36, p-trend = 0.03). On the contrary, a marginally inverse association was observed for total fish intake and BC risk among men (HR comparing highest with lowest tertile: 0.79, 95% CI 0.65, 0.97, p-trend = 0.04). No associations were observed for other meat sources. Results of this prospective study suggest that organ meat consumption may be associated with BC development. Replication in large-scale prospective studies and investigation of possible causal mechanisms is needed.

KW - Bladder cancer

KW - Meat

KW - Fish

KW - Risk factor

KW - Epidemiology

KW - COLORECTAL-CANCER

KW - COOKING METHODS

KW - DIET DIVERSITY

KW - EPIC PROJECT

KW - LUNG-CANCER

KW - FATTY-ACIDS

KW - RED MEAT

KW - DESIGN

KW - WOMEN

KW - RATIONALE

U2 - 10.1007/s10654-021-00762-4

DO - 10.1007/s10654-021-00762-4

M3 - Journal article

C2 - 34036467

VL - 36

SP - 781

EP - 792

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

ER -