The effect of dietary estimates calculated using food frequency questionnaires on micronuclei formation in European pregnant women: a NewGeneris study

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The effect of dietary estimates calculated using food frequency questionnaires on micronuclei formation in European pregnant women : a NewGeneris study. / Vande Loock, Kim; Botsivali, Maria; Zangogianni, Marina; Anderson, Diana; Baumgartner, Adolph; Fthenou, Eleni; Chatzi, Leda; Marcos, Ricard; Agramunt, Sylvia; Namork, Ellen; Granum, Berit; Knudsen, Lisbeth E.; Nielssen, Jeanette K S; Meltzer, Helle Margrete; Haugen, Margaretha; Kyrtopoulos, Soterios A; Decordier, Ilse; Plas, Gina; Roelants, Mathieu; Merlo, Franco; Kleinjans, Jos; Kogevinas, Manolis; Kirsch-Volders, Micheline.

In: Mutagenesis, Vol. 29, No. 6, 11.2014, p. 393-400.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Vande Loock, K, Botsivali, M, Zangogianni, M, Anderson, D, Baumgartner, A, Fthenou, E, Chatzi, L, Marcos, R, Agramunt, S, Namork, E, Granum, B, Knudsen, LE, Nielssen, JKS, Meltzer, HM, Haugen, M, Kyrtopoulos, SA, Decordier, I, Plas, G, Roelants, M, Merlo, F, Kleinjans, J, Kogevinas, M & Kirsch-Volders, M 2014, 'The effect of dietary estimates calculated using food frequency questionnaires on micronuclei formation in European pregnant women: a NewGeneris study', Mutagenesis, vol. 29, no. 6, pp. 393-400. https://doi.org/10.1093/mutage/geu052

APA

Vande Loock, K., Botsivali, M., Zangogianni, M., Anderson, D., Baumgartner, A., Fthenou, E., ... Kirsch-Volders, M. (2014). The effect of dietary estimates calculated using food frequency questionnaires on micronuclei formation in European pregnant women: a NewGeneris study. Mutagenesis, 29(6), 393-400. https://doi.org/10.1093/mutage/geu052

Vancouver

Vande Loock K, Botsivali M, Zangogianni M, Anderson D, Baumgartner A, Fthenou E et al. The effect of dietary estimates calculated using food frequency questionnaires on micronuclei formation in European pregnant women: a NewGeneris study. Mutagenesis. 2014 Nov;29(6):393-400. https://doi.org/10.1093/mutage/geu052

Author

Vande Loock, Kim ; Botsivali, Maria ; Zangogianni, Marina ; Anderson, Diana ; Baumgartner, Adolph ; Fthenou, Eleni ; Chatzi, Leda ; Marcos, Ricard ; Agramunt, Sylvia ; Namork, Ellen ; Granum, Berit ; Knudsen, Lisbeth E. ; Nielssen, Jeanette K S ; Meltzer, Helle Margrete ; Haugen, Margaretha ; Kyrtopoulos, Soterios A ; Decordier, Ilse ; Plas, Gina ; Roelants, Mathieu ; Merlo, Franco ; Kleinjans, Jos ; Kogevinas, Manolis ; Kirsch-Volders, Micheline. / The effect of dietary estimates calculated using food frequency questionnaires on micronuclei formation in European pregnant women : a NewGeneris study. In: Mutagenesis. 2014 ; Vol. 29, No. 6. pp. 393-400.

Bibtex

@article{a0ca9a9d50a149dfbcf8fcaf3a5d5f28,
title = "The effect of dietary estimates calculated using food frequency questionnaires on micronuclei formation in European pregnant women: a NewGeneris study",
abstract = "The use of biomarkers of early genetic effects, predictive for cancer, such as micronuclei (MN) in lymphocytes, may help to investigate the association between diet and cancer. We hypothesised that the presence of mutagens in the diet may increase MN formation. A 'pooled' standardised analysis was performed by applying the same experimental protocol for the cytokinesis block micronucleus assay in 625 young healthy women after delivery from five European study populations (Greece, Denmark, UK, Spain and Norway). We assessed MN frequencies in mono- and binucleated T-lymphocytes (MNMONO and MNBN) and the cytokinesis blocked proliferation index using a semi-automated image analysis system. Food frequency questionnaires (FFQs) were used to estimate intake of fatty acids and a broad range of immunotoxic and genotoxic/carcinogenic compounds through the diet. Pooled difference based on delivery type revealed higher MNMONO frequencies in caesarean than in vaginal delivery (P = 0.002). Statistical analysis showed a decrease in MNMONO frequencies with increasing calculated omega-6 PUFA concentrations and a decrease in MNBN frequencies with increasing calculated omega-3 PUFA concentrations. The expected toxic compounds estimated by FFQs were not associated with MN formation in mothers after delivery. In pregnant women, an omega-3 and -6 rich diet estimated by FFQ is associated with lower MN formation during pregnancy and delivery.",
author = "{Vande Loock}, Kim and Maria Botsivali and Marina Zangogianni and Diana Anderson and Adolph Baumgartner and Eleni Fthenou and Leda Chatzi and Ricard Marcos and Sylvia Agramunt and Ellen Namork and Berit Granum and Knudsen, {Lisbeth E.} and Nielssen, {Jeanette K S} and Meltzer, {Helle Margrete} and Margaretha Haugen and Kyrtopoulos, {Soterios A} and Ilse Decordier and Gina Plas and Mathieu Roelants and Franco Merlo and Jos Kleinjans and Manolis Kogevinas and Micheline Kirsch-Volders",
note = "{\circledC} The Author 2014. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2014",
month = "11",
doi = "10.1093/mutage/geu052",
language = "English",
volume = "29",
pages = "393--400",
journal = "Mutagenesis",
issn = "0267-8357",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - The effect of dietary estimates calculated using food frequency questionnaires on micronuclei formation in European pregnant women

T2 - a NewGeneris study

AU - Vande Loock, Kim

AU - Botsivali, Maria

AU - Zangogianni, Marina

AU - Anderson, Diana

AU - Baumgartner, Adolph

AU - Fthenou, Eleni

AU - Chatzi, Leda

AU - Marcos, Ricard

AU - Agramunt, Sylvia

AU - Namork, Ellen

AU - Granum, Berit

AU - Knudsen, Lisbeth E.

AU - Nielssen, Jeanette K S

AU - Meltzer, Helle Margrete

AU - Haugen, Margaretha

AU - Kyrtopoulos, Soterios A

AU - Decordier, Ilse

AU - Plas, Gina

AU - Roelants, Mathieu

AU - Merlo, Franco

AU - Kleinjans, Jos

AU - Kogevinas, Manolis

AU - Kirsch-Volders, Micheline

N1 - © The Author 2014. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2014/11

Y1 - 2014/11

N2 - The use of biomarkers of early genetic effects, predictive for cancer, such as micronuclei (MN) in lymphocytes, may help to investigate the association between diet and cancer. We hypothesised that the presence of mutagens in the diet may increase MN formation. A 'pooled' standardised analysis was performed by applying the same experimental protocol for the cytokinesis block micronucleus assay in 625 young healthy women after delivery from five European study populations (Greece, Denmark, UK, Spain and Norway). We assessed MN frequencies in mono- and binucleated T-lymphocytes (MNMONO and MNBN) and the cytokinesis blocked proliferation index using a semi-automated image analysis system. Food frequency questionnaires (FFQs) were used to estimate intake of fatty acids and a broad range of immunotoxic and genotoxic/carcinogenic compounds through the diet. Pooled difference based on delivery type revealed higher MNMONO frequencies in caesarean than in vaginal delivery (P = 0.002). Statistical analysis showed a decrease in MNMONO frequencies with increasing calculated omega-6 PUFA concentrations and a decrease in MNBN frequencies with increasing calculated omega-3 PUFA concentrations. The expected toxic compounds estimated by FFQs were not associated with MN formation in mothers after delivery. In pregnant women, an omega-3 and -6 rich diet estimated by FFQ is associated with lower MN formation during pregnancy and delivery.

AB - The use of biomarkers of early genetic effects, predictive for cancer, such as micronuclei (MN) in lymphocytes, may help to investigate the association between diet and cancer. We hypothesised that the presence of mutagens in the diet may increase MN formation. A 'pooled' standardised analysis was performed by applying the same experimental protocol for the cytokinesis block micronucleus assay in 625 young healthy women after delivery from five European study populations (Greece, Denmark, UK, Spain and Norway). We assessed MN frequencies in mono- and binucleated T-lymphocytes (MNMONO and MNBN) and the cytokinesis blocked proliferation index using a semi-automated image analysis system. Food frequency questionnaires (FFQs) were used to estimate intake of fatty acids and a broad range of immunotoxic and genotoxic/carcinogenic compounds through the diet. Pooled difference based on delivery type revealed higher MNMONO frequencies in caesarean than in vaginal delivery (P = 0.002). Statistical analysis showed a decrease in MNMONO frequencies with increasing calculated omega-6 PUFA concentrations and a decrease in MNBN frequencies with increasing calculated omega-3 PUFA concentrations. The expected toxic compounds estimated by FFQs were not associated with MN formation in mothers after delivery. In pregnant women, an omega-3 and -6 rich diet estimated by FFQ is associated with lower MN formation during pregnancy and delivery.

U2 - 10.1093/mutage/geu052

DO - 10.1093/mutage/geu052

M3 - Journal article

VL - 29

SP - 393

EP - 400

JO - Mutagenesis

JF - Mutagenesis

SN - 0267-8357

IS - 6

ER -

ID: 137757321