The effect of changing diagnostic method from culture to PCR on the number of episodes of human campylobacteriosis in Denmark: a retrospective study (2015-2022)

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  • Benedetti, Guido
  • Christian Holm Hansen
  • Anna Tølbøll Svendsen
  • Katrine Grimstrup Joensen
  • Gitte Sørensen
  • Anne Line Engsbro
  • Mia Torpdahl
  • Eva Møller Nielsen
  • Ethelberg, Steen

This study is important because it shows the potential epidemiological silence associated with the use of culture as the primary diagnostic method for the laboratory identification of human campylobacteriosis. Also, we show how polymerase chain reaction methods are associated with a systematic increase in the number of human campylobacteriosis episodes as reported by routine disease surveillance. These findings are operationally relevant and have public health implications because they tell how crucial it is to consider changes in diagnostic methods, e.g., in the epidemiological analysis of historical data and in the interpretation of future data in light of the past. We also believe that this study highlights how the synergy between microbiology and epidemiology is essential for disease surveillance.

Original languageEnglish
Article numbere0341823
JournalMicrobiology Spectrum
Issue number1
Number of pages12
Publication statusPublished - 2024

ID: 376887096