Effect of postsurgical rehabilitation programmes in patients operated for lung cancer: A systematic review and meta-analysis
Research output: Contribution to journal › Review › Research › peer-review
Standard
Effect of postsurgical rehabilitation programmes in patients operated for lung cancer : A systematic review and meta-analysis. / Sommer, Maja S.; Staerkind, Maja E. B.; Christensen, Jan; Vibe-Petersen, Jette; Larsen, Klaus R; Holst Pedersen, Jesper; Langberg, Henning.
In: Journal of Rehabilitation Medicine, Vol. 50, No. 3, 03.2018, p. 236-245.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Effect of postsurgical rehabilitation programmes in patients operated for lung cancer
T2 - A systematic review and meta-analysis
AU - Sommer, Maja S.
AU - Staerkind, Maja E. B.
AU - Christensen, Jan
AU - Vibe-Petersen, Jette
AU - Larsen, Klaus R
AU - Holst Pedersen, Jesper
AU - Langberg, Henning
PY - 2018/3
Y1 - 2018/3
N2 - OBJECTIVE: To review the evidence concerning the effects of postoperative exercise interventions on exercise capacity and health-related quality of life following resection for non-small cell lung cancer, and to review whether different initiation times of exercise produce different effects on exercise capacity.DATA SOURCES: Comprehensive literature search of MEDLINE, Embase, CENTRAL, CINAHL and PEDro.STUDY SELECTION: Randomized controlled trials examining the effects of exercise interventions were eligible for inclusion.DATA EXTRACTION: Postoperative outcome measurements were extracted and the quality of evidence was graded using Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group.DATA SYNTHESIS: Four randomized controlled trials were identified involving 262 participants. Short-term follow-up (12-20 weeks) showed significantly higher exercise capacity and physical component of health-related quality of life in the intervention group (standardized mean difference (SMD) 0.48; 95% confidence interval (CI) 0.04-0.93) compared with the control group (SMD 0.50; 95% CI 0.19-0.82). There was no difference between the effect of late- and early-initiated exercise intervention.CONCLUSION: Exercise has a small-to-moderate effect at short-term follow-up on exercise capacity and the physical component of health-related quality of life in patients operated for lung cancer. The long-term effects of exercise capacity are unknown. Early-initiated exercise programmes (2 weeks post-operation) did not show an effect on exercise capacity. These findings should be interpreted with caution.
AB - OBJECTIVE: To review the evidence concerning the effects of postoperative exercise interventions on exercise capacity and health-related quality of life following resection for non-small cell lung cancer, and to review whether different initiation times of exercise produce different effects on exercise capacity.DATA SOURCES: Comprehensive literature search of MEDLINE, Embase, CENTRAL, CINAHL and PEDro.STUDY SELECTION: Randomized controlled trials examining the effects of exercise interventions were eligible for inclusion.DATA EXTRACTION: Postoperative outcome measurements were extracted and the quality of evidence was graded using Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group.DATA SYNTHESIS: Four randomized controlled trials were identified involving 262 participants. Short-term follow-up (12-20 weeks) showed significantly higher exercise capacity and physical component of health-related quality of life in the intervention group (standardized mean difference (SMD) 0.48; 95% confidence interval (CI) 0.04-0.93) compared with the control group (SMD 0.50; 95% CI 0.19-0.82). There was no difference between the effect of late- and early-initiated exercise intervention.CONCLUSION: Exercise has a small-to-moderate effect at short-term follow-up on exercise capacity and the physical component of health-related quality of life in patients operated for lung cancer. The long-term effects of exercise capacity are unknown. Early-initiated exercise programmes (2 weeks post-operation) did not show an effect on exercise capacity. These findings should be interpreted with caution.
U2 - 10.2340/16501977-2292
DO - 10.2340/16501977-2292
M3 - Review
C2 - 29392334
VL - 50
SP - 236
EP - 245
JO - Journal of Rehabilitation Medicine
JF - Journal of Rehabilitation Medicine
SN - 1650-1977
IS - 3
ER -
ID: 195590935