High circulating levels of tumor necrosis factor-alpha in centenarians are not associated with increased production in T lymphocytes

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Standard

High circulating levels of tumor necrosis factor-alpha in centenarians are not associated with increased production in T lymphocytes. / Sandmand, Marie; Bruunsgaard, Helle; Kemp, Kåre; Andersen-Ranberg, Karen; Schroll, Marianne; Jeune, Bernard.

In: Gerontology, Vol. 49, No. 3, 2003, p. 155-60.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sandmand, M, Bruunsgaard, H, Kemp, K, Andersen-Ranberg, K, Schroll, M & Jeune, B 2003, 'High circulating levels of tumor necrosis factor-alpha in centenarians are not associated with increased production in T lymphocytes', Gerontology, vol. 49, no. 3, pp. 155-60. https://doi.org/10.1159/000069174

APA

Sandmand, M., Bruunsgaard, H., Kemp, K., Andersen-Ranberg, K., Schroll, M., & Jeune, B. (2003). High circulating levels of tumor necrosis factor-alpha in centenarians are not associated with increased production in T lymphocytes. Gerontology, 49(3), 155-60. https://doi.org/10.1159/000069174

Vancouver

Sandmand M, Bruunsgaard H, Kemp K, Andersen-Ranberg K, Schroll M, Jeune B. High circulating levels of tumor necrosis factor-alpha in centenarians are not associated with increased production in T lymphocytes. Gerontology. 2003;49(3):155-60. https://doi.org/10.1159/000069174

Author

Sandmand, Marie ; Bruunsgaard, Helle ; Kemp, Kåre ; Andersen-Ranberg, Karen ; Schroll, Marianne ; Jeune, Bernard. / High circulating levels of tumor necrosis factor-alpha in centenarians are not associated with increased production in T lymphocytes. In: Gerontology. 2003 ; Vol. 49, No. 3. pp. 155-60.

Bibtex

@article{084b31701a4711df8ed1000ea68e967b,
title = "High circulating levels of tumor necrosis factor-alpha in centenarians are not associated with increased production in T lymphocytes",
abstract = "BACKGROUND: Aging is characterized by increased inflammatory activity reflected by increased plasma levels of proinflammatory cytokines, concomitant with an altered cytokine profile of T lymphocytes. High plasma levels of tumor necrosis factor (TNF)-alpha are strongly associated with morbidity and mortality in elderly humans. However, the cellular source and mechanisms for the increased circulating TNF-alpha levels are unknown. OBJECTIVE: The aim of the present study was to investigate if high plasma levels of TNF-alpha are associated with increased production of TNF-alpha by T lymphocytes in elderly humans. METHODS: TNF-alpha production by CD4+ and CD8+ T lymphocytes was measured by flow cytometry following stimulation with phorbol 12-myristate 13-acetate and ionomycin in 28 young controls, 14, 81-year-olds and 25 centenarians. RESULTS: Plasma levels of TNF-alpha increased with increasing age. An increased percentage and number of T lymphocytes from the 81 year olds expressed TNF-alpha, whereas centenarians did not show this altered TNF-alpha secretion profile. CONCLUSION: T cells may contribute to the elevated levels of plasma TNF-alpha in healthy elderly subjects, whereas other mechanisms are responsible in very old individuals.",
author = "Marie Sandmand and Helle Bruunsgaard and K{\aa}re Kemp and Karen Andersen-Ranberg and Marianne Schroll and Bernard Jeune",
note = "Keywords: Adult; Aged; Aged, 80 and over; Female; Humans; Lymphocyte Activation; Male; T-Lymphocytes; Tumor Necrosis Factor-alpha",
year = "2003",
doi = "10.1159/000069174",
language = "English",
volume = "49",
pages = "155--60",
journal = "Gerontology",
issn = "0304-324X",
publisher = "S Karger AG",
number = "3",

}

RIS

TY - JOUR

T1 - High circulating levels of tumor necrosis factor-alpha in centenarians are not associated with increased production in T lymphocytes

AU - Sandmand, Marie

AU - Bruunsgaard, Helle

AU - Kemp, Kåre

AU - Andersen-Ranberg, Karen

AU - Schroll, Marianne

AU - Jeune, Bernard

N1 - Keywords: Adult; Aged; Aged, 80 and over; Female; Humans; Lymphocyte Activation; Male; T-Lymphocytes; Tumor Necrosis Factor-alpha

PY - 2003

Y1 - 2003

N2 - BACKGROUND: Aging is characterized by increased inflammatory activity reflected by increased plasma levels of proinflammatory cytokines, concomitant with an altered cytokine profile of T lymphocytes. High plasma levels of tumor necrosis factor (TNF)-alpha are strongly associated with morbidity and mortality in elderly humans. However, the cellular source and mechanisms for the increased circulating TNF-alpha levels are unknown. OBJECTIVE: The aim of the present study was to investigate if high plasma levels of TNF-alpha are associated with increased production of TNF-alpha by T lymphocytes in elderly humans. METHODS: TNF-alpha production by CD4+ and CD8+ T lymphocytes was measured by flow cytometry following stimulation with phorbol 12-myristate 13-acetate and ionomycin in 28 young controls, 14, 81-year-olds and 25 centenarians. RESULTS: Plasma levels of TNF-alpha increased with increasing age. An increased percentage and number of T lymphocytes from the 81 year olds expressed TNF-alpha, whereas centenarians did not show this altered TNF-alpha secretion profile. CONCLUSION: T cells may contribute to the elevated levels of plasma TNF-alpha in healthy elderly subjects, whereas other mechanisms are responsible in very old individuals.

AB - BACKGROUND: Aging is characterized by increased inflammatory activity reflected by increased plasma levels of proinflammatory cytokines, concomitant with an altered cytokine profile of T lymphocytes. High plasma levels of tumor necrosis factor (TNF)-alpha are strongly associated with morbidity and mortality in elderly humans. However, the cellular source and mechanisms for the increased circulating TNF-alpha levels are unknown. OBJECTIVE: The aim of the present study was to investigate if high plasma levels of TNF-alpha are associated with increased production of TNF-alpha by T lymphocytes in elderly humans. METHODS: TNF-alpha production by CD4+ and CD8+ T lymphocytes was measured by flow cytometry following stimulation with phorbol 12-myristate 13-acetate and ionomycin in 28 young controls, 14, 81-year-olds and 25 centenarians. RESULTS: Plasma levels of TNF-alpha increased with increasing age. An increased percentage and number of T lymphocytes from the 81 year olds expressed TNF-alpha, whereas centenarians did not show this altered TNF-alpha secretion profile. CONCLUSION: T cells may contribute to the elevated levels of plasma TNF-alpha in healthy elderly subjects, whereas other mechanisms are responsible in very old individuals.

U2 - 10.1159/000069174

DO - 10.1159/000069174

M3 - Journal article

C2 - 12679605

VL - 49

SP - 155

EP - 160

JO - Gerontology

JF - Gerontology

SN - 0304-324X

IS - 3

ER -

ID: 17657060