Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India

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Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India. / Dhar, Mahesh S.; Marwal, Robin; Radhakrishnan, V. S.; Ponnusamy, Kalaiarasan; Jolly, Bani; Bhoyar, Rahul C.; Sardana, Viren; Naushin, Salwa; Rophina, Mercy; Mellan, Thomas A.; Mishra, Swapnil; Whittaker, Charles; Fatihi, Saman; Datta, Meena; Singh, Priyanka; Sharma, Uma; Ujjainiya, Rajat; Bhatheja, Nitin; Divakar, Mohit Kumar; Singh, Manoj K.; Imran, Mohamed; Senthivel, Vigneshwar; Maurya, Ranjeet; Jha, Neha; Mehta, Priyanka; Vivekanand, A.; Sharma, Pooja; Arvinden, V. R.; Chaudhary, Urmila; Soni, Namita; Thukral, Lipi; Flaxman, Seth; Bhatt, Samir; Pandey, Rajesh; Dash, Debasis; Faruq, Mohammed; Lall, Hemlata; Gogia, Hema; Madan, Preeti; Kulkarni, Sanket; Chauhan, Himanshu; Sengupta, Shantanu; Kabra, Sandhya; Gupta, Ravindra K.; Singh, Sujeet K.; Agrawal, Anurag; Rakshit, Partha.

In: Science, Vol. 374, No. 6570, 2021, p. 995-999.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Dhar, MS, Marwal, R, Radhakrishnan, VS, Ponnusamy, K, Jolly, B, Bhoyar, RC, Sardana, V, Naushin, S, Rophina, M, Mellan, TA, Mishra, S, Whittaker, C, Fatihi, S, Datta, M, Singh, P, Sharma, U, Ujjainiya, R, Bhatheja, N, Divakar, MK, Singh, MK, Imran, M, Senthivel, V, Maurya, R, Jha, N, Mehta, P, Vivekanand, A, Sharma, P, Arvinden, VR, Chaudhary, U, Soni, N, Thukral, L, Flaxman, S, Bhatt, S, Pandey, R, Dash, D, Faruq, M, Lall, H, Gogia, H, Madan, P, Kulkarni, S, Chauhan, H, Sengupta, S, Kabra, S, Gupta, RK, Singh, SK, Agrawal, A & Rakshit, P 2021, 'Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India', Science, vol. 374, no. 6570, pp. 995-999. https://doi.org/10.1126/science.abj9932

APA

Dhar, M. S., Marwal, R., Radhakrishnan, V. S., Ponnusamy, K., Jolly, B., Bhoyar, R. C., Sardana, V., Naushin, S., Rophina, M., Mellan, T. A., Mishra, S., Whittaker, C., Fatihi, S., Datta, M., Singh, P., Sharma, U., Ujjainiya, R., Bhatheja, N., Divakar, M. K., ... Rakshit, P. (2021). Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India. Science, 374(6570), 995-999. https://doi.org/10.1126/science.abj9932

Vancouver

Dhar MS, Marwal R, Radhakrishnan VS, Ponnusamy K, Jolly B, Bhoyar RC et al. Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India. Science. 2021;374(6570):995-999. https://doi.org/10.1126/science.abj9932

Author

Dhar, Mahesh S. ; Marwal, Robin ; Radhakrishnan, V. S. ; Ponnusamy, Kalaiarasan ; Jolly, Bani ; Bhoyar, Rahul C. ; Sardana, Viren ; Naushin, Salwa ; Rophina, Mercy ; Mellan, Thomas A. ; Mishra, Swapnil ; Whittaker, Charles ; Fatihi, Saman ; Datta, Meena ; Singh, Priyanka ; Sharma, Uma ; Ujjainiya, Rajat ; Bhatheja, Nitin ; Divakar, Mohit Kumar ; Singh, Manoj K. ; Imran, Mohamed ; Senthivel, Vigneshwar ; Maurya, Ranjeet ; Jha, Neha ; Mehta, Priyanka ; Vivekanand, A. ; Sharma, Pooja ; Arvinden, V. R. ; Chaudhary, Urmila ; Soni, Namita ; Thukral, Lipi ; Flaxman, Seth ; Bhatt, Samir ; Pandey, Rajesh ; Dash, Debasis ; Faruq, Mohammed ; Lall, Hemlata ; Gogia, Hema ; Madan, Preeti ; Kulkarni, Sanket ; Chauhan, Himanshu ; Sengupta, Shantanu ; Kabra, Sandhya ; Gupta, Ravindra K. ; Singh, Sujeet K. ; Agrawal, Anurag ; Rakshit, Partha. / Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India. In: Science. 2021 ; Vol. 374, No. 6570. pp. 995-999.

Bibtex

@article{8c660a115e424e659b053463b4687621,

title = "Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India",

abstract = "Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, B.1.617.2 (Delta), replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates: 1.5-fold greater transmissibility and 20% reduction in sensitivity). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi.",

author = "Dhar, {Mahesh S.} and Robin Marwal and Radhakrishnan, {V. S.} and Kalaiarasan Ponnusamy and Bani Jolly and Bhoyar, {Rahul C.} and Viren Sardana and Salwa Naushin and Mercy Rophina and Mellan, {Thomas A.} and Swapnil Mishra and Charles Whittaker and Saman Fatihi and Meena Datta and Priyanka Singh and Uma Sharma and Rajat Ujjainiya and Nitin Bhatheja and Divakar, {Mohit Kumar} and Singh, {Manoj K.} and Mohamed Imran and Vigneshwar Senthivel and Ranjeet Maurya and Neha Jha and Priyanka Mehta and A. Vivekanand and Pooja Sharma and Arvinden, {V. R.} and Urmila Chaudhary and Namita Soni and Lipi Thukral and Seth Flaxman and Samir Bhatt and Rajesh Pandey and Debasis Dash and Mohammed Faruq and Hemlata Lall and Hema Gogia and Preeti Madan and Sanket Kulkarni and Himanshu Chauhan and Shantanu Sengupta and Sandhya Kabra and Gupta, {Ravindra K.} and Singh, {Sujeet K.} and Anurag Agrawal and Partha Rakshit",

year = "2021",

doi = "10.1126/science.abj9932",

language = "English",

volume = "374",

pages = "995--999",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6570",

}

RIS

TY - JOUR

T1 - Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India

AU - Dhar, Mahesh S.

AU - Marwal, Robin

AU - Radhakrishnan, V. S.

AU - Ponnusamy, Kalaiarasan

AU - Jolly, Bani

AU - Bhoyar, Rahul C.

AU - Sardana, Viren

AU - Naushin, Salwa

AU - Rophina, Mercy

AU - Mellan, Thomas A.

AU - Mishra, Swapnil

AU - Whittaker, Charles

AU - Fatihi, Saman

AU - Datta, Meena

AU - Singh, Priyanka

AU - Sharma, Uma

AU - Ujjainiya, Rajat

AU - Bhatheja, Nitin

AU - Divakar, Mohit Kumar

AU - Singh, Manoj K.

AU - Imran, Mohamed

AU - Senthivel, Vigneshwar

AU - Maurya, Ranjeet

AU - Jha, Neha

AU - Mehta, Priyanka

AU - Vivekanand, A.

AU - Sharma, Pooja

AU - Arvinden, V. R.

AU - Chaudhary, Urmila

AU - Soni, Namita

AU - Thukral, Lipi

AU - Flaxman, Seth

AU - Bhatt, Samir

AU - Pandey, Rajesh

AU - Dash, Debasis

AU - Faruq, Mohammed

AU - Lall, Hemlata

AU - Gogia, Hema

AU - Madan, Preeti

AU - Kulkarni, Sanket

AU - Chauhan, Himanshu

AU - Sengupta, Shantanu

AU - Kabra, Sandhya

AU - Gupta, Ravindra K.

AU - Singh, Sujeet K.

AU - Agrawal, Anurag

AU - Rakshit, Partha

PY - 2021

Y1 - 2021

N2 - Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, B.1.617.2 (Delta), replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates: 1.5-fold greater transmissibility and 20% reduction in sensitivity). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi.

AB - Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, B.1.617.2 (Delta), replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates: 1.5-fold greater transmissibility and 20% reduction in sensitivity). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi.

U2 - 10.1126/science.abj9932

DO - 10.1126/science.abj9932

M3 - Journal article

C2 - 34648303

AN - SCOPUS:85118619545

VL - 374

SP - 995

EP - 999

JO - Science

JF - Science

SN - 0036-8075

IS - 6570

ER -

ID: 286493629

Department of Public Health