The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

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The overlapping burden of the three leading causes of disability and death in sub-Saharan African children. / LBD Triple Burden Collaborators.

In: Nature Communications, Vol. 13, No. 1, 7457, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

LBD Triple Burden Collaborators 2022, 'The overlapping burden of the three leading causes of disability and death in sub-Saharan African children', Nature Communications, vol. 13, no. 1, 7457. https://doi.org/10.1038/s41467-022-34240-6

APA

LBD Triple Burden Collaborators (2022). The overlapping burden of the three leading causes of disability and death in sub-Saharan African children. Nature Communications, 13(1), [7457]. https://doi.org/10.1038/s41467-022-34240-6

Vancouver

LBD Triple Burden Collaborators. The overlapping burden of the three leading causes of disability and death in sub-Saharan African children. Nature Communications. 2022;13(1). 7457. https://doi.org/10.1038/s41467-022-34240-6

Author

LBD Triple Burden Collaborators. / The overlapping burden of the three leading causes of disability and death in sub-Saharan African children. In: Nature Communications. 2022 ; Vol. 13, No. 1.

Bibtex

@article{a87a33edf6d24936891ef8362e6f267b,
title = "The overlapping burden of the three leading causes of disability and death in sub-Saharan African children",
abstract = "Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival.",
author = "Reiner, {Robert C.} and Welgan, {Catherine A.} and Troeger, {Christopher E.} and Baumann, {Mathew M.} and Weiss, {Daniel J.} and Aniruddha Deshpande and Blacker, {Brigette F.} and Miller-Petrie, {Molly K.} and Lucas Earl and Samir Bhatt and Hassan Abolhassani and Abosetugn, {Akine Eshete} and Eman Abu-Gharbieh and Victor Adekanmbi and Adetokunboh, {Olatunji O.} and Mohammad Aghaali and Budi Aji and Fares Alahdab and Ziyad Al-Aly and Alhassan, {Robert Kaba} and Saqib Ali and Hesam Alizade and Aljunid, {Syed Mohamed} and Amir Almasi-Hashiani and Al-Mekhlafi, {Hesham M.} and Altirkawi, {Khalid A.} and Nelson Alvis-Guzman and Amare, {Azmeraw T.} and Saeed Amini and Amugsi, {Dickson A.} and Robert Ancuceanu and Andrei, {Catalina Liliana} and Fereshteh Ansari and Davood Anvari and Appiah, {Seth Christopher Yaw} and Jalal Arabloo and Olatunde Aremu and Atout, {Maha Moh{\textquoteright}d Wahbi} and Marcel Ausloos and Floriane Ausloos and Ayanore, {Martin Amogre} and Aynalem, {Yared Asmare} and Azene, {Zelalem Nigussie} and Alaa Badawi and Baig, {Atif Amin} and Maciej Banach and Neeraj Bedi and Bhagavathula, {Akshaya Srikanth} and Dinesh Bhandari and Nikha Bhardwaj and {LBD Triple Burden Collaborators}",
note = "Funding Information: This work was primarily supported by grant OPP1132415 from the Bill & Melinda Gates Foundation. Funding Information: This study was funded by the Bill & Melinda Gates Foundation. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. The non-consortium authors have no competing interests . Competing interests for consortium authors is as follows: Robert Ancuceanu reports receiving consultancy or speaker feeds from UCB, Sandoz, Abbvie, Zentiva, Teva, Laropharm, CEGEDIM, Angelini, Biessen Pharma, Hofigal, AstraZeneca, and Stada. Jacek Jerzy Jozwiak reports personal fees from Amgen, ALAB Laboratories, Teva, Synexus, Boehringer Ingelheim, and Zentiva, all outside the submitted work. Kewal Krishan reports non-financial support from UGC Centre of Advanced Study, CAS II, Department of Anthropology, Panjab University, Chandigarh, India, outside the submitted work. Walter Mendoza is a Program Analyst in Population and Development at the United Nations Population Fund-UNFPA Country Office in Peru, which does not necessarily endorse or support these findings. Maarten J Postma reports grants and personal fees from MSD, GSK, Pfizer, Boehringer Ingelheim, Novavax, BMS, Seqirus, Astra Zeneca, Sanofi, IQVIA, grants from Bayer, BioMerieux, WHO, EU, FIND, Antilope, DIKTI, LPDP, Budi, personal fees from Novartis, Quintiles, Pharmerit, owning stock options in Health-Ecore and PAG Ltd, and being advisor to Asc Academics, all outside the submitted work. Jasviner A Singh reports personal fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio health, Medscape, WebMD, Clinical Care options, Clearview healthcare partners, Putnam associates, Focus forward, Navigant consulting, Spherix, Practice Point communications, the National Institutes of Health, the American College of Rheumatology, and Simply Speaking, owning stock options in Amarin, Viking, Moderna, Vaxart pharmaceuticals and Charlotte{\textquoteright}s Web Holdings, being a member of FDA Arthritis Advisory Committee, the steering committee of OMERACT, an international organization that develops measures for clinical trials and receives arm{\textquoteright}s length funding from 12 pharmaceutical companies, and the Veterans Affairs Rheumatology Field Advisory Committee, and acting as Editor and Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis, all outside the submitted work. Era Upadhyay has a patent A system and method of reusable filters for anti-pollution mask pending, and a patent A system and method for electricity generation through crop stubble by using microbial fuel cells pending. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
doi = "10.1038/s41467-022-34240-6",
language = "English",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

AU - Reiner, Robert C.

AU - Welgan, Catherine A.

AU - Troeger, Christopher E.

AU - Baumann, Mathew M.

AU - Weiss, Daniel J.

AU - Deshpande, Aniruddha

AU - Blacker, Brigette F.

AU - Miller-Petrie, Molly K.

AU - Earl, Lucas

AU - Bhatt, Samir

AU - Abolhassani, Hassan

AU - Abosetugn, Akine Eshete

AU - Abu-Gharbieh, Eman

AU - Adekanmbi, Victor

AU - Adetokunboh, Olatunji O.

AU - Aghaali, Mohammad

AU - Aji, Budi

AU - Alahdab, Fares

AU - Al-Aly, Ziyad

AU - Alhassan, Robert Kaba

AU - Ali, Saqib

AU - Alizade, Hesam

AU - Aljunid, Syed Mohamed

AU - Almasi-Hashiani, Amir

AU - Al-Mekhlafi, Hesham M.

AU - Altirkawi, Khalid A.

AU - Alvis-Guzman, Nelson

AU - Amare, Azmeraw T.

AU - Amini, Saeed

AU - Amugsi, Dickson A.

AU - Ancuceanu, Robert

AU - Andrei, Catalina Liliana

AU - Ansari, Fereshteh

AU - Anvari, Davood

AU - Appiah, Seth Christopher Yaw

AU - Arabloo, Jalal

AU - Aremu, Olatunde

AU - Atout, Maha Moh’d Wahbi

AU - Ausloos, Marcel

AU - Ausloos, Floriane

AU - Ayanore, Martin Amogre

AU - Aynalem, Yared Asmare

AU - Azene, Zelalem Nigussie

AU - Badawi, Alaa

AU - Baig, Atif Amin

AU - Banach, Maciej

AU - Bedi, Neeraj

AU - Bhagavathula, Akshaya Srikanth

AU - Bhandari, Dinesh

AU - Bhardwaj, Nikha

AU - LBD Triple Burden Collaborators

N1 - Funding Information: This work was primarily supported by grant OPP1132415 from the Bill & Melinda Gates Foundation. Funding Information: This study was funded by the Bill & Melinda Gates Foundation. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. The non-consortium authors have no competing interests . Competing interests for consortium authors is as follows: Robert Ancuceanu reports receiving consultancy or speaker feeds from UCB, Sandoz, Abbvie, Zentiva, Teva, Laropharm, CEGEDIM, Angelini, Biessen Pharma, Hofigal, AstraZeneca, and Stada. Jacek Jerzy Jozwiak reports personal fees from Amgen, ALAB Laboratories, Teva, Synexus, Boehringer Ingelheim, and Zentiva, all outside the submitted work. Kewal Krishan reports non-financial support from UGC Centre of Advanced Study, CAS II, Department of Anthropology, Panjab University, Chandigarh, India, outside the submitted work. Walter Mendoza is a Program Analyst in Population and Development at the United Nations Population Fund-UNFPA Country Office in Peru, which does not necessarily endorse or support these findings. Maarten J Postma reports grants and personal fees from MSD, GSK, Pfizer, Boehringer Ingelheim, Novavax, BMS, Seqirus, Astra Zeneca, Sanofi, IQVIA, grants from Bayer, BioMerieux, WHO, EU, FIND, Antilope, DIKTI, LPDP, Budi, personal fees from Novartis, Quintiles, Pharmerit, owning stock options in Health-Ecore and PAG Ltd, and being advisor to Asc Academics, all outside the submitted work. Jasviner A Singh reports personal fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio health, Medscape, WebMD, Clinical Care options, Clearview healthcare partners, Putnam associates, Focus forward, Navigant consulting, Spherix, Practice Point communications, the National Institutes of Health, the American College of Rheumatology, and Simply Speaking, owning stock options in Amarin, Viking, Moderna, Vaxart pharmaceuticals and Charlotte’s Web Holdings, being a member of FDA Arthritis Advisory Committee, the steering committee of OMERACT, an international organization that develops measures for clinical trials and receives arm’s length funding from 12 pharmaceutical companies, and the Veterans Affairs Rheumatology Field Advisory Committee, and acting as Editor and Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis, all outside the submitted work. Era Upadhyay has a patent A system and method of reusable filters for anti-pollution mask pending, and a patent A system and method for electricity generation through crop stubble by using microbial fuel cells pending. Publisher Copyright: © 2022, The Author(s).

PY - 2022

Y1 - 2022

N2 - Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival.

AB - Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival.

U2 - 10.1038/s41467-022-34240-6

DO - 10.1038/s41467-022-34240-6

M3 - Journal article

C2 - 36473841

AN - SCOPUS:85143491451

VL - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 7457

ER -

ID: 385515948