Cancer predictive value of cytogenetic markers used in occupational health surveillance programs

Research output: Contribution to journalJournal articleResearchpeer-review

L Hagmar, S Bonassi, U Strömberg, Z Mikoczy, C Lando, I L Hansteen, A H Montagud, Lisbeth E. Knudsen, H Norppa, C Reuterwall, H Tinnerberg, A Brøgger, A Forni, B Högstedt, B Lambert, F Mitelman, I Nordenson, S Salomaa, S Skerfving

It has not previously been clear whether cytogenetic biomarkers in healthy subjects will predict cancer. Earlier analyses of a Nordic and an Italian cohort indicated predictivity for chromosomal aberrations (CAS) but not for sister chromatid exchanges (SCES). A pooled analysis of the updated cohorts, forming a joint study base of 5271 subjects, will now be performed, allowing a more solid evaluation. The importance of potential effect modifiers, such as gender, age at testing, and time since testing, will be evaluated using Poisson regression models. Two other potential effect modifiers, occupational exposures and smoking, will be assessed in a case-referent study within the study base.
Original languageEnglish
Book seriesRecent Results in Cancer Research
Volume154
Pages (from-to)177-84
Number of pages7
ISSN0080-0015
Publication statusPublished - 1998

Bibliographical note

Keywords: Biological Markers; Chromosome Aberrations; Health Surveys; Humans; Incidence; Micronuclei, Chromosome-Defective; Neoplasms; Occupational Health; Sister Chromatid Exchange

ID: 17557490