Effect of praziquantel on human lymphocyte proliferation in vitro

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Standard

Effect of praziquantel on human lymphocyte proliferation in vitro. / Odum, Niels; Theander, T G; Bygbjerg, I C.

In: European Journal of Clinical Pharmacology, Vol. 27, No. 3, 1984, p. 311-3.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Odum, N, Theander, TG & Bygbjerg, IC 1984, 'Effect of praziquantel on human lymphocyte proliferation in vitro', European Journal of Clinical Pharmacology, vol. 27, no. 3, pp. 311-3.

APA

Odum, N., Theander, T. G., & Bygbjerg, I. C. (1984). Effect of praziquantel on human lymphocyte proliferation in vitro. European Journal of Clinical Pharmacology, 27(3), 311-3.

Vancouver

Odum N, Theander TG, Bygbjerg IC. Effect of praziquantel on human lymphocyte proliferation in vitro. European Journal of Clinical Pharmacology. 1984;27(3):311-3.

Author

Odum, Niels ; Theander, T G ; Bygbjerg, I C. / Effect of praziquantel on human lymphocyte proliferation in vitro. In: European Journal of Clinical Pharmacology. 1984 ; Vol. 27, No. 3. pp. 311-3.

Bibtex

@article{1d81e9a0a0de11dd86a6000ea68e967b,
title = "Effect of praziquantel on human lymphocyte proliferation in vitro",
abstract = "The antischistosomal drugs tartar emetic and niridazole exert immunosuppression both in vitro and in vivo. In the present study the influence of praziquantel (Biltricide), a potent schistosomicidal drug, on human lymphocyte proliferation in vitro was investigated. Praziquantel 80 micrograms/ml significantly reduced thymidine incorporation by human blood mononuclear cells stimulated with mitogens and antigens, whereas no effect could be detected in concentrations below 40 micrograms/ml. Thus, praziquantel, in concentrations as high as 30 times the peak serum concentration during therapy, has no suppressive effect on human lymphocyte proliferation in vitro.",
author = "Niels Odum and Theander, {T G} and Bygbjerg, {I C}",
note = "Keywords: Adult; Dose-Response Relationship, Drug; Female; Humans; Isoquinolines; Lymphocyte Activation; Male; Praziquantel",
year = "1984",
language = "English",
volume = "27",
pages = "311--3",
journal = "European Journal of Clinical Pharmacology",
issn = "0031-6970",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Effect of praziquantel on human lymphocyte proliferation in vitro

AU - Odum, Niels

AU - Theander, T G

AU - Bygbjerg, I C

N1 - Keywords: Adult; Dose-Response Relationship, Drug; Female; Humans; Isoquinolines; Lymphocyte Activation; Male; Praziquantel

PY - 1984

Y1 - 1984

N2 - The antischistosomal drugs tartar emetic and niridazole exert immunosuppression both in vitro and in vivo. In the present study the influence of praziquantel (Biltricide), a potent schistosomicidal drug, on human lymphocyte proliferation in vitro was investigated. Praziquantel 80 micrograms/ml significantly reduced thymidine incorporation by human blood mononuclear cells stimulated with mitogens and antigens, whereas no effect could be detected in concentrations below 40 micrograms/ml. Thus, praziquantel, in concentrations as high as 30 times the peak serum concentration during therapy, has no suppressive effect on human lymphocyte proliferation in vitro.

AB - The antischistosomal drugs tartar emetic and niridazole exert immunosuppression both in vitro and in vivo. In the present study the influence of praziquantel (Biltricide), a potent schistosomicidal drug, on human lymphocyte proliferation in vitro was investigated. Praziquantel 80 micrograms/ml significantly reduced thymidine incorporation by human blood mononuclear cells stimulated with mitogens and antigens, whereas no effect could be detected in concentrations below 40 micrograms/ml. Thus, praziquantel, in concentrations as high as 30 times the peak serum concentration during therapy, has no suppressive effect on human lymphocyte proliferation in vitro.

M3 - Journal article

C2 - 6510458

VL - 27

SP - 311

EP - 313

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

SN - 0031-6970

IS - 3

ER -

ID: 6767436