In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines

Research output: Contribution to journal › Journal article › peer-review

Standard

In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines. / Roursgaard, Martin; Knudsen, Kristina Bram; Northeved, Helle; Persson, Mikael; Christensen, Tina; Kumar, Pramod E. K.; Permin, Anders; Andresen, Thomas L.; Gjetting, Torben; Lykkesfeldt, Jens; Vesterdal, Lise K.; Loft, Steffen; Møller, Peter.

In: Toxicology in Vitro, Vol. 36, 10.2016, p. 164-171.

Research output: Contribution to journal › Journal article › peer-review

Harvard

Roursgaard, M, Knudsen, KB, Northeved, H, Persson, M, Christensen, T, Kumar, PEK, Permin, A, Andresen, TL, Gjetting, T, Lykkesfeldt, J, Vesterdal, LK, Loft, S & Møller, P 2016, 'In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines', Toxicology in Vitro, vol. 36, pp. 164-171. https://doi.org/10.1016/j.tiv.2016.08.002

APA

Roursgaard, M., Knudsen, K. B., Northeved, H., Persson, M., Christensen, T., Kumar, P. E. K., Permin, A., Andresen, T. L., Gjetting, T., Lykkesfeldt, J., Vesterdal, L. K., Loft, S., & Møller, P. (2016). In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines. Toxicology in Vitro, 36, 164-171. https://doi.org/10.1016/j.tiv.2016.08.002

Vancouver

Roursgaard M, Knudsen KB, Northeved H, Persson M, Christensen T, Kumar PEK et al. In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines. Toxicology in Vitro. 2016 Oct;36:164-171. https://doi.org/10.1016/j.tiv.2016.08.002

Author

Roursgaard, Martin ; Knudsen, Kristina Bram ; Northeved, Helle ; Persson, Mikael ; Christensen, Tina ; Kumar, Pramod E. K. ; Permin, Anders ; Andresen, Thomas L. ; Gjetting, Torben ; Lykkesfeldt, Jens ; Vesterdal, Lise K. ; Loft, Steffen ; Møller, Peter. / In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines. In: Toxicology in Vitro. 2016 ; Vol. 36. pp. 164-171.

Bibtex

@article{561ed11de96b49db8efdf54ba27c96e6,
title = "In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines",
abstract = "The aim of this study was to compare the effects of cationic micelle and liposome drug delivery systems on liver and lung cells in a toxicological in vitro screening model, with observations on cytotoxicity and genotoxicity. A screening battery was established for assessment of a broad range of parameters related to adverse effects. Clear concentration response effects were observed related to impairment of mitochondrial function, membrane integrity and oxidative stress markers, but no effect was observed on genotoxicity. The adverse effects were highest for the liposomes. The High Content Screening seems optimal for initial screening of adverse effects, and combined with standard cytotoxicity measurements initial screening can be performed for predictive toxicological screening.",
keywords = "Journal Article",
author = "Martin Roursgaard and Knudsen, {Kristina Bram} and Helle Northeved and Mikael Persson and Tina Christensen and Kumar, {Pramod E. K.} and Anders Permin and Andresen, {Thomas L.} and Torben Gjetting and Jens Lykkesfeldt and Vesterdal, {Lise K.} and Steffen Loft and Peter M{\o}ller",
note = "Copyright {\textcopyright} 2016 Elsevier Ltd. All rights reserved.",
year = "2016",
month = oct,
doi = "10.1016/j.tiv.2016.08.002",
language = "English",
volume = "36",
pages = "164--171",
journal = "Toxicology in Vitro",
issn = "0887-2333",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines

AU - Roursgaard, Martin

AU - Knudsen, Kristina Bram

AU - Northeved, Helle

AU - Persson, Mikael

AU - Christensen, Tina

AU - Kumar, Pramod E. K.

AU - Permin, Anders

AU - Andresen, Thomas L.

AU - Gjetting, Torben

AU - Lykkesfeldt, Jens

AU - Vesterdal, Lise K.

AU - Loft, Steffen

AU - Møller, Peter

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016/10

Y1 - 2016/10

N2 - The aim of this study was to compare the effects of cationic micelle and liposome drug delivery systems on liver and lung cells in a toxicological in vitro screening model, with observations on cytotoxicity and genotoxicity. A screening battery was established for assessment of a broad range of parameters related to adverse effects. Clear concentration response effects were observed related to impairment of mitochondrial function, membrane integrity and oxidative stress markers, but no effect was observed on genotoxicity. The adverse effects were highest for the liposomes. The High Content Screening seems optimal for initial screening of adverse effects, and combined with standard cytotoxicity measurements initial screening can be performed for predictive toxicological screening.

AB - The aim of this study was to compare the effects of cationic micelle and liposome drug delivery systems on liver and lung cells in a toxicological in vitro screening model, with observations on cytotoxicity and genotoxicity. A screening battery was established for assessment of a broad range of parameters related to adverse effects. Clear concentration response effects were observed related to impairment of mitochondrial function, membrane integrity and oxidative stress markers, but no effect was observed on genotoxicity. The adverse effects were highest for the liposomes. The High Content Screening seems optimal for initial screening of adverse effects, and combined with standard cytotoxicity measurements initial screening can be performed for predictive toxicological screening.

KW - Journal Article

U2 - 10.1016/j.tiv.2016.08.002

DO - 10.1016/j.tiv.2016.08.002

M3 - Journal article

C2 - 27497994

VL - 36

SP - 164

EP - 171

JO - Toxicology in Vitro

JF - Toxicology in Vitro

SN - 0887-2333

ER -

ID: 165568160