The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP-1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients

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Standard

The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP-1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients. / Juul, A; Main, K; Blum, W F; Lindholm, Jesper; Ranke, M B; Skakkebaek, N E.

In: Clinical Endocrinology, Vol. 41, No. 1, 1994, p. 85-93.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Juul, A, Main, K, Blum, WF, Lindholm, J, Ranke, MB & Skakkebaek, NE 1994, 'The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP-1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients', Clinical Endocrinology, vol. 41, no. 1, pp. 85-93.

APA

Juul, A., Main, K., Blum, W. F., Lindholm, J., Ranke, M. B., & Skakkebaek, N. E. (1994). The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP-1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients. Clinical Endocrinology, 41(1), 85-93.

Vancouver

Juul A, Main K, Blum WF, Lindholm J, Ranke MB, Skakkebaek NE. The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP-1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients. Clinical Endocrinology. 1994;41(1):85-93.

Author

Juul, A ; Main, K ; Blum, W F ; Lindholm, Jesper ; Ranke, M B ; Skakkebaek, N E. / The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP-1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients. In: Clinical Endocrinology. 1994 ; Vol. 41, No. 1. pp. 85-93.

Bibtex

@article{322b900001344afa98b2419e2f2540ed,
title = "The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP-1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients",
abstract = "Several in-vitro studies have suggested that the biological actions of IGF-I can be modified by the presence of specific IGF binding proteins. In man, the 24-hour serum levels of IGF-I and IGFBP-3 remain constant, but short-term changes in the IGF-I/IGFBP-3 ratio have been described following GH administration. Serum levels of IGF-I and IGFBP-3 decrease with age in normal adults and are elevated in active acromegaly due to excessive GH secretion. However, the individual ratios between serum levels of IGF-I and IGFBP-3 in acromegalic and healthy adults have not been described previously.",
author = "A Juul and K Main and Blum, {W F} and Jesper Lindholm and Ranke, {M B} and Skakkebaek, {N E}",
year = "1994",
language = "English",
volume = "41",
pages = "85--93",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - The ratio between serum levels of insulin-like growth factor (IGF)-I and the IGF binding proteins (IGFBP-1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients

AU - Juul, A

AU - Main, K

AU - Blum, W F

AU - Lindholm, Jesper

AU - Ranke, M B

AU - Skakkebaek, N E

PY - 1994

Y1 - 1994

N2 - Several in-vitro studies have suggested that the biological actions of IGF-I can be modified by the presence of specific IGF binding proteins. In man, the 24-hour serum levels of IGF-I and IGFBP-3 remain constant, but short-term changes in the IGF-I/IGFBP-3 ratio have been described following GH administration. Serum levels of IGF-I and IGFBP-3 decrease with age in normal adults and are elevated in active acromegaly due to excessive GH secretion. However, the individual ratios between serum levels of IGF-I and IGFBP-3 in acromegalic and healthy adults have not been described previously.

AB - Several in-vitro studies have suggested that the biological actions of IGF-I can be modified by the presence of specific IGF binding proteins. In man, the 24-hour serum levels of IGF-I and IGFBP-3 remain constant, but short-term changes in the IGF-I/IGFBP-3 ratio have been described following GH administration. Serum levels of IGF-I and IGFBP-3 decrease with age in normal adults and are elevated in active acromegaly due to excessive GH secretion. However, the individual ratios between serum levels of IGF-I and IGFBP-3 in acromegalic and healthy adults have not been described previously.

M3 - Journal article

VL - 41

SP - 85

EP - 93

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 1

ER -

ID: 48486888