The role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: A review

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Ali Kermanizadeh, Caroline Chauché, David M Brown, Steffen Loft, Peter Møller

The terms oxidative stress, free radical generation, and intracellular antioxidant protection have become part of everyday nanotoxicology terminology. In recent years, an ever increasing number of in vitro and in vivo studies have implicated disruptions to the redox balance and oxidative stress as one of the main contributors to nanomaterial (NM) induced adverse effects. One of the most important and widely investigated of these effects is genotoxicity. In general, systems that defend an organism against oxidative damage to DNA are very complex and include prevention of reactive oxygen species (ROS) production, neutralizing ROS (scavengers), enzymatic nucleotide pool sanitation, and DNA repair. This review discusses the importance of the maintenance of the redox balance in this context before examining studies that have investigated engineered NM induced redox imbalance and genotoxicity. Furthermore, we identify data gaps, and highlight a number of issues that exist with the methodologies that are routinely utilized to investigate intracellular ROS production or anti-oxidant depletion. We conclude that for a large number of engineered NM types changes in the redox balance toward oxidative stress are normally associated with DNA damage.

Original languageEnglish
JournalEnvironmental and Molecular Mutagenesis
Volume56
Issue number2
Pages (from-to)111-24
Number of pages14
ISSN0893-6692
DOIs
Publication statusPublished - Mar 2015

Bibliographical note

Corrigendum to “the role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: A review.” DOI: 10.1002/em.22175

ID: 132417933