Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men
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Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men. / Benson, Thea Emily; Gaml-Sorensen, Anne; Ernst, Andreas; Brix, Nis; Hougaard, Karin Sørig; Haervig, Katia Keglberg; Ellekilde Bonde, Jens Peter; Tøttenborg, Sandra Søgaard; Lindh, Christian H.; Ramlau-Hansen, Cecilia Host; Toft, Gunnar.
In: International Journal of Environmental Research and Public Health, Vol. 18, No. 4, 1742, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men
AU - Benson, Thea Emily
AU - Gaml-Sorensen, Anne
AU - Ernst, Andreas
AU - Brix, Nis
AU - Hougaard, Karin Sørig
AU - Haervig, Katia Keglberg
AU - Ellekilde Bonde, Jens Peter
AU - Tøttenborg, Sandra Søgaard
AU - Lindh, Christian H.
AU - Ramlau-Hansen, Cecilia Host
AU - Toft, Gunnar
PY - 2021
Y1 - 2021
N2 - Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are structurally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross-sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18-20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concentration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile-divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre-pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population.
AB - Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are structurally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross-sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18-20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concentration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile-divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre-pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population.
KW - bisphenol
KW - endocrine disruptor
KW - epidemiology
KW - male fertility
KW - semen quality
U2 - 10.3390/ijerph18041742
DO - 10.3390/ijerph18041742
M3 - Journal article
C2 - 33670148
VL - 18
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
IS - 4
M1 - 1742
ER -
ID: 258613612