Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract

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Standard

Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. / Blomberg Jensen, Martin; Nielsen, John E; Jørgensen, Anne; Rajpert-De Meyts, Ewa; Kristensen, David Møbjerg; Jørgensen, Niels; Skakkebæk, Niels Erik; Juul, Anders; Leffers, Henrik.

In: Human Reproduction, Vol. 25, No. 5, 01.05.2010, p. 1303-11.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Blomberg Jensen, M, Nielsen, JE, Jørgensen, A, Rajpert-De Meyts, E, Kristensen, DM, Jørgensen, N, Skakkebæk, NE, Juul, A & Leffers, H 2010, 'Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract', Human Reproduction, vol. 25, no. 5, pp. 1303-11. https://doi.org/10.1093/humrep/deq024

APA

Blomberg Jensen, M., Nielsen, J. E., Jørgensen, A., Rajpert-De Meyts, E., Kristensen, D. M., Jørgensen, N., Skakkebæk, N. E., Juul, A., & Leffers, H. (2010). Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Human Reproduction, 25(5), 1303-11. https://doi.org/10.1093/humrep/deq024

Vancouver

Blomberg Jensen M, Nielsen JE, Jørgensen A, Rajpert-De Meyts E, Kristensen DM, Jørgensen N et al. Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Human Reproduction. 2010 May 1;25(5):1303-11. https://doi.org/10.1093/humrep/deq024

Author

Blomberg Jensen, Martin ; Nielsen, John E ; Jørgensen, Anne ; Rajpert-De Meyts, Ewa ; Kristensen, David Møbjerg ; Jørgensen, Niels ; Skakkebæk, Niels Erik ; Juul, Anders ; Leffers, Henrik. / Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. In: Human Reproduction. 2010 ; Vol. 25, No. 5. pp. 1303-11.

Bibtex

@article{bbb135f9521746e2ab58f18e7ec26315,
title = "Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract",
abstract = "The vitamin D receptor (VDR) is expressed in human testis, and vitamin D (VD) has been suggested to affect survival and function of mature spermatozoa. Indeed, VDR knockout mice and VD deficient rats show decreased sperm counts and low fertility. However, the cellular response to VD is complex, since it is not solely dependent on VDR expression, but also on cellular uptake of circulating VD and presence and activity of VD metabolizing enzymes. Expression of VD metabolizing enzymes has not previously been investigated in human testis and male reproductive tract. Therefore, we performed a comprehensive analysis of the expression of VDR, VD activating (CYP2R1, CYP27A1, CYP27B1) and inactivating (CYP24A1) enzymes in the testis, epididymis, seminal vesicle (SV), prostate and spermatozoa.",
author = "{Blomberg Jensen}, Martin and Nielsen, {John E} and Anne J{\o}rgensen and {Rajpert-De Meyts}, Ewa and Kristensen, {David M{\o}bjerg} and Niels J{\o}rgensen and Skakkeb{\ae}k, {Niels Erik} and Anders Juul and Henrik Leffers",
year = "2010",
month = may,
day = "1",
doi = "http://dx.doi.org/10.1093/humrep/deq024",
language = "English",
volume = "25",
pages = "1303--11",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford Academic",
number = "5",

}

RIS

TY - JOUR

T1 - Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract

AU - Blomberg Jensen, Martin

AU - Nielsen, John E

AU - Jørgensen, Anne

AU - Rajpert-De Meyts, Ewa

AU - Kristensen, David Møbjerg

AU - Jørgensen, Niels

AU - Skakkebæk, Niels Erik

AU - Juul, Anders

AU - Leffers, Henrik

PY - 2010/5/1

Y1 - 2010/5/1

N2 - The vitamin D receptor (VDR) is expressed in human testis, and vitamin D (VD) has been suggested to affect survival and function of mature spermatozoa. Indeed, VDR knockout mice and VD deficient rats show decreased sperm counts and low fertility. However, the cellular response to VD is complex, since it is not solely dependent on VDR expression, but also on cellular uptake of circulating VD and presence and activity of VD metabolizing enzymes. Expression of VD metabolizing enzymes has not previously been investigated in human testis and male reproductive tract. Therefore, we performed a comprehensive analysis of the expression of VDR, VD activating (CYP2R1, CYP27A1, CYP27B1) and inactivating (CYP24A1) enzymes in the testis, epididymis, seminal vesicle (SV), prostate and spermatozoa.

AB - The vitamin D receptor (VDR) is expressed in human testis, and vitamin D (VD) has been suggested to affect survival and function of mature spermatozoa. Indeed, VDR knockout mice and VD deficient rats show decreased sperm counts and low fertility. However, the cellular response to VD is complex, since it is not solely dependent on VDR expression, but also on cellular uptake of circulating VD and presence and activity of VD metabolizing enzymes. Expression of VD metabolizing enzymes has not previously been investigated in human testis and male reproductive tract. Therefore, we performed a comprehensive analysis of the expression of VDR, VD activating (CYP2R1, CYP27A1, CYP27B1) and inactivating (CYP24A1) enzymes in the testis, epididymis, seminal vesicle (SV), prostate and spermatozoa.

U2 - http://dx.doi.org/10.1093/humrep/deq024

DO - http://dx.doi.org/10.1093/humrep/deq024

M3 - Journal article

VL - 25

SP - 1303

EP - 1311

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 5

ER -

ID: 34048031