Perinatal, Obstetric & Paediatric Epidemiology (POPE)
The research group is conducting epidemiologic research, mainly focused on maternal, child and adolescent health. Additionally, the research group examines how conditions during pregnancy and early life influence the health of the child later in life.
The group holds special interest in the ways of which health and health trajectories are impacted by social and environmental conditions from fetal life over childhood and adolescence to early adulthood.
Key words of our research are: social patterning of disease – birth cohorts - developmental origin of health and disease – mental health in children and youth – urban environment – indoor environment – preterm birth – eating disorders – migrant reproductive health – spinal pain – congenital anomalies – infections.
The specific projects within the research group:
DNBC is a cohort of almost 100,000 individuals, born 1996-2003, who have been followed since intrauterine life.
Contact: Professor Anne-Marie Nybo Andersen (Principle Investigator of DNBC) and Katrine Strandberg-Larsen (Co-PI of DNBC)
The 18 years follow-up
The 18-year follow-up of DNBC youth focused on mental health among the young participants and was completes December 2021.
Contact: Associate professor Katrine Strandberg-Larsen (Co-PI of DNBC)
The COVID-19 survey within the DNBC was initiated in the third week of the national lockdown. All participants, both the youths and the mothers, of whom we had information of private mail and/or phone numbers, were contacted. Participants completing the survey were re-invited up to 7 times during the initial lockdown. Approximately one year subsequent to the initial lockdown, all participants were invited for wave 8.
Contact: PhD fellow Andrea Joensen
Planning a 25 year follow-up
This follow-up is under planning and will focus on social career, health and family formation.
All DNBC participants living on the island of Funen were invited for a clinical examination with the aim of exploring the prevalence of Celiac Disease, causes and consequences.
Contact: Professor Steffen Husby (Syddansk Universitet)
The Corona Pandemic and everyday life
This study is part of the research project “Standing together – at a distance. How Danes are living with the Corona Crisis” and a sub research from the Danish National Birth Cohort. We explore how the Corona Pandemic affect Danes’ mental well-being and everyday life, and how or if it changes over time.
The LifeSpine research program is designed to identify potential domains for intervention and relevant target groups for prevention of childhood spinal pain.
Indoor environment and child health
The aim of the RealChild project is to investigate the various impacts of housing and indoor environment on children’s health in the DNBC. The 11-year DNBC follow-up has a large number of questionnaire items regarding the indoor home environment, which is the primary source used to characterize children’s exposures. The outcomes of primary focus are related to infectious diseases, asthma, and mental health.
Pets and respiratory health
Should your family get a cat to prevent asthma – or get rid of it? And what about dogs? Do family history or genes affect the answer to these questions?
Contact: Post Doc Angela Pinot de Moira
Read about the project under Mental health in youth.
PIA Psoriasis in Children
Risk factors and prognosis of psoriasis in children.
Contact: Professor Anne-Marie Nybo Andersen or Professor Lone Skov (Gentofte Hospital)
The aim of the interactive website www.Birthcohorts.net is to facilitate exchange of knowledge and collaboration between birth cohorts and researchers. In addition, we would like to provide administrators, policy makers and other stakeholders information about available birth cohort data on health and its determinants.
Horizon 2020 projects
The POPE group is a partner in the Horizon 2020-funded projects EUCAN-Connect and ATHLETE, which are cross-cohort collaborations bringing together data from pregnancy and child cohorts from across Europe, Canada and Australia to facilitate studies on the influence of early-life exposures on cardio-metabolic, respiratory and mental health outcomes.
EUCAN-Connect is focused on the infrastructure and creating a sustainable framework for long-term collaboration, while ATHLETE is focused on studying how different early-life exposures influence health later on.
Contact: Professor Anne-Marie Nybo Andersen (EUCAN-Connect), Associate Professor Katrine Strandberg-Larsen (ATHLETE), Associate Professor Marie Pedersen (ATHLETE)) or Data Scientist Luise Cederkvist Kristiansen (EUCAN-Connect/ATHLETE)
Visit: https://eucanconnect.eu and https://athleteproject.eu
EU Child Cohort Network
The network is a collaboration between more than 20 birth cohorts that enables federated analyses of harmonized longitudinal birth cohort data.
The ECCN was established within the LifeCycle project but is now used and enriched within the ATHLETE and EUCAN-Connect consortium. The harmonized data from all participating cohorts are made FAIR (findable, accessible, interoperable and reusable).
In order to make data interoperable, participating cohorts are required to harmonise and pseudonymise their individual level data. That is, using the original data collected by cohorts to create new measures that are comparable across cohorts, and replacing directly identifiable information, which could be used to identify an individual, with a pseudonym.
In order to make data findable and reusable, participating cohorts are required to provide and upload harmonisation documentation to open and searchable online variable catalogues.
Finally, in order to make data accessible, participating cohorts are required to set up an infrastructure where harmonised and pseudonymised cohort data are stored locally on servers and researchers with approved research studies can conduct federated analyses via a Central Analysis Server.
EUChild Cohort Network, EUCAN-Connect and ATHLETE apply DataSHIELD, which is a software solution for secure collaboration and can be used to conduct federated analyses. This Data+ project, funded by the University of Copenhagen, explores the opportunities as well as ethico-legal challenges and implications of using DataSHIELD for cross-border analysis of sensitive birth cohort data.
Maternal stress and risk of preterm birth
Contact: PhD fellow Julie Bergeron or Professor Anne-Marie Nybo Andersen
Is gestational age at birth causally related to body dimensions later in life?
The project investigates the association of gestational age at birth with later body dimensions from infancy through adolescence in three separate, yet related, research projects: (1) across 16 birth cohorts in more than 250,000 singletons using federated analysis within DataSHIELD, (2) from a life-course perspective with trajectories of height and body mass index in the Danish National Birth Cohort, and (3) in relation to birth size focusing on the risk of underweight and overweight at 18 years.
The EATus program investigates whether there is empirically evidence for a spectral nature of Eating Disorders, develop algorithms to predict for whom early symptoms will persist, progress into EDs or resolve across adolescence, and finally explore the etiological mechanisms underlying EDs.
The YRSA project investigates risk factors of suicide attempts and the provided mental health care to young people in suicidal crisis. Furthermore, the project identify barriers and facilitating factors related to seeking professional mental health treatment in the aftermath of adolescent suicidal behavior.
Contact: Senior Researcher Trine Madsen (Psychiatrics Gentofte Hospital)
How does the early mother-child bonding affect mental health in childhood and adolescence
Contact: PhD Fellow Ida Scheel Rasmussen or Associate Professor Katrine Strandberg-Larsen
Urbinex aims to understand the pathways through which lower socioeconomic position is related to poorer mental health outcomes in children. Using data from multiple EU birth cohorts, it seeks to understand whether greater exposure to urban environmental stressors (such as noise and air pollution) mediates associations between socioeconomic position and child mental health. URBINEX is embedded within both the LifeCycle and ATHLETE consortia.
Contact: Postdoc Timothy James Cadman
The DanCHASE project (Danish Child Health And Social Equity project)
In this project we examine how health conditions during pregnancy and childhood vary according to social conditions.
The WELLIFE project: Welfare state life courses; Social inequalities in the co-evolution of employment, health and critical life events
The WELLIFE project is a NordForsk funded project using Nordic register data to explore the co-evolution of health and social factors over the life course. Social conditions, such as income, employment and family resources, matter for health, and health matters for participation in society, employment and economic well-being. These associations are well known. What is not that well known is whether social policy, including labour market policies, modifies the extent to which the onset of illness affect living conditions, in particular employment. Also, the role of social policy in the extent to which critical life events, such as job loss, divorce or health shocks within the close family, translate into poor health and worse living conditions for parents and children. These are some of the questions investigated in the WELLIFE project.
The SCOPE project
The SCOPE (Scandinavian studies of COvid-19 in PrEgnancy) project is funded by the NordForsk. By the use of national registry data from Denmark, Sweden and Norway, this project aims to fill three crucial knowledge gaps related to COVID-19 and pregnancy:
- Are pregnant women at higher risk for COVID-19 than non-pregnant
- Is COVID-19 associated with adverse pregnancy outcomes, including fetal loss?
- Can maternal COVID-19 harm the foetus and new-born?
The EUROlinkCAT is funded by the EU’s Horizon 2020 research and innovation programme. EUROlinkCAT uses the EUROCAT infrastructure (population-based registries for surveillance of congenital anomalies) to support 21 EUROCAT registries in 13 European countries to link their congenital anomaly data to mortality, hospital discharge, prescription and educational databases. One big aim of the EUROlinkCAT is to investigate the health and educational outcomes of children with congenital anomalies for the first 10 years of their lives. In total, an estimated 200,000 children born between 1995-2014 is included. The project is based at Kolding Sygehus. You can read more about the EUROlinkCAT here: www.eurolinkcat.eu/home
MAMAACT is a universal complex intervention project that seeks to strengthen pregnant women’s response to disease symptoms, and to improve the communication between women and the health care system. Register-based studies have supported the intervention and quantitative analyses of the intervention is being conducted.
Members of research group
|Search in Name||Search in Title||Search in Phone|
|Joensen, Andrea||PhD Fellow||+4535327313|
|Kristiansen, Luise Cederkvist||Data Manager||+4535327059|
|Mikkelsen, Nadia Mirsharghi||Student||+4535331150|
|Nybo Andersen, Anne-Marie||Professor||+4535326765|
|Schmidt, Lise Kristine Højsgaard||Academic Staff||+4535334666|
|Strandberg-Larsen, Katrine||Associate Professor - Promotion Programme||+4535326078|
|Urhøj, Stine Kjær||Assistant Professor||+4535327142|
|V Varga, Tibor||Associate Professor||+4535327739|
|Andersen, Sofie Thor||Videnscenter om Spiseforstyrrelser og Selvskade|
|Aurup, Anne V.||Department of Nutrition, Exercise and Sports|
|Bergeron, Julie||McGill UNiversity|
|Danielsen, Stine||Psyciatrics Gentofte Hospital|
|Hjern, Anders||Karolinska Institute|
|Nielsen, Karoline Kragelund||Steno Diabetes Center Copenhagen|
|Rasmussen, Ida Scheel||Section of General Practice|
|Taylor-Robinson, David||University of Liverpool|